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The BIOFIRE System and Your Immune System

The BIOFIRE System offers syndromic testing for infectious diseases, allowing healthcare providers to select the appropriate test first time. Patients benefit from faster diagnosis and a more specific treatment. Clinicians benefit from improved antibiotic stewardship. Labs improve efficiency and cost savings.

The BioFire Pneumonia Plus Panel (PN panel) tests native sputum (including mini-BAL) as well as endotracheal sludge and bronchoalveolar Slurries (including mini BAL) for 33 clinically significant pathogens and resistance genes to antimicrobials within an hour.

Respiratory

The burning of biomass (wood plants, trees and other organic materials) creates gaseous pollutants and fine particulate matter that negatively impact the respiratory system. Climate change may increase the negative effects of forest bio-ethanol fires on human health.

In the United States wildfire smoke is linked to hospitalizations due to respiratory illnesses like asthma, COPD, and lung cancer. Additionally, this kind of air pollution is a risk factor for cardiovascular diseases and a major contributor to the burden of illness for the most vulnerable population which includes those who are of lower socioeconomic status (SES).

During the COVID-19 epidemic, many communities were exposed to harmful levels of air pollution resulting from wildfires. However, the public health response to this environmental issue is sporadic and mainly focused on communicating about symptom management. This knowledge gap is alarming given the evidence that smoking cigarettes and other sources of air pollution can lead to health problems.

Researchers are now looking at the best methods to safeguard public health during future events of this type. NIH invests in research on this important public health issue through the BLUE CORAL and FIRE CORAL studies.

For the first time an prospective cohort study will assess long-term outcomes from exposure to smoke from wildfires as well as other sources. FIRE CORAL enrolls adults who are hospitalized for COVID-19 index episode and who speak English or Spanish, but are not pregnant. The Fire Coral protocol includes a battery in-person assessments that objectively measure the pulmonary function testing lung imaging and functional assessment.

Smoke and other particles can cause or worsen chronic respiratory conditions like emphysema COPD and pneumonia. There are a variety of steps that can be taken to stop or minimize the negative health effects from short-term exposures to smoke, such as avoiding outdoor activities when feasible and wearing the EPA's "N95" mask that is designed to trap fine particles.

Smoking cigarettes can cause irritation of the throat and eyes and can cause a runny nose. To reduce the symptoms, the lungs should be flushed with plenty of water and taking medicines which reduce inflammation, like corticosteroids.

Bloodstream

Your bloodstream is on the front lines of fighting germs that enter your body. Dendritic cells are special cells, function as a call center for your fire department. They are able to collect antigens from bacteria and release proteins to alert other white cells to fight off them. Circulating white blood cells, differentials, and band cells were boosted during firefighters' firefighting shifts, compared with levels after strenuous physical exertion with no firefighting.

Skin

Dermatologists were concerned that the smoke and ash of the California wildfires could cause negative effects on the skin of those exposed to these substances. Maria Wei is a graduate student from University of California, Irvine. She examines how extreme wildfire pollution affects the skin. Her research was published on April 22 2012 in Scientific Reports.

Wei's research has shown that the temperature of a person's skin changes depending on how long the body is exposed to flames. It could take up to two hours for the skin of someone to reach their "flash point"--the place where it begins to burn and turn to ash. It is important to avoid staying near a campfire or fire, and you should always wear protective clothing if you're going outside on a hot or humid day.

Forest fires will continue to happen, despite the precautions taken to stop wildfire pollution. Wei believes that as the climate changes cause forests to burn faster, the number of people suffering from wildfires will rise. This means that more people will be required to wear long sleeves, hats, and thick moisturizers.

It's also worth knowing that atopic dermatitis (itchy skin) that many people suffer from can be made worse by air pollution from wildfires. The particles in smoke can block pores and cause atopic skin to become worse.

Another issue is that atopic dermatitis tends to make people more sensitive to UV light, which may be aggravated by smoke from wildfires. This can result in people looking for tanning salons and apply a tan with less protection.

A treatment using ice and fire may help reduce atopic skin symptoms of dermatitis however it is not recommended for those with an open wound or rash. This treatment is not recommended for those who have active acne, or if you're pregnant or nursing. The IS Clinical Fire & Ice Facial at Novuskin, Las Vegas' top membership MedSpa offers a thorough result-driven facial that bridges the gap between a gentle facial and a peel, without having to wait for any downtime. It's designed to rejuvenate skin, improve rosacea, decrease the appearance of acne scars and fine lines and stimulate cellular renewal. It's a fantastic treatment to give yourself a radiant glow.

Infections

The human body is a multi-faceted network of organs and tissues that work together to protect us from infection. Infections can be caused by microorganisms, such as parasites, viruses, and bacteria which infect healthy cells, causing them to multiply uncontrollably. When this occurs, your immune system may react with symptoms of illness. These symptoms can be anything from a snoring nose to a stomach that is upset as well as an increase in fever, swelling of lymph glands or a rash. The nature of the infection and its location can affect the severity of your symptoms.

Infections can spread in a variety of ways but the most prevalent are spread from person to through droplets that linger in the air after coughing or Ethanol biofuel fireplace sneezing. This is how bacterial infections like strep, tuberculosis and meningococcal disease and viral infections like the common cold and influenza are spread. Some bacterial infections such as skin infections or sexually transmitted diseases (STIs) such as Chlamydia and gonorrhea can be transmitted through direct contact with infected mucous or tissue surfaces, or indirectly through surfaces that are contaminated. Some bacterial diseases are carried by bugs like ticks, mosquitoes or fleas. They can be spread when these bugs bite you.

The parasites, viruses, and other microorganisms are tiny enough that they can enter your bloodstream to infect your cells. This can result in serious illnesses such as the common cold or AIDS. Fungi are responsible for a myriad of skin conditions such as ringworm and athlete's foot. Some are a threat to the lungs and nervous system, Ethanol Fuel Fireplace like the rabies virus.

The BioFire Panel uses our innovative FilmArray technology to analyze sputum and bronchoalveolar fluid samples for a comprehensive listing of pathogens that are involved in upper respiratory infection. The kit includes the reagent pouch which stores all the necessary chemistry to perform reverse transcription PCR, nested analysis and detection on a single machine. This is a simple solution that aids clinicians in identifying and indoor ethanol fireplaces (have a peek here) treat patients with a variety respiratory symptoms. This test has been granted an Emergency Use Authorization and is available through bioMerieux's CLIA moderate and high complexity labs.